Uranium in PDB 3s82: Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium

All present enzymatic activity of Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium:
2.5.1.6;

The structure of Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium, PDB code: 3s82 was solved by Seattle Structural Genomics Center For Infectious Disease, Seattlestructural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.73
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	60.030, 88.180, 184.190, 90.00, 90.00, 90.00
R / Rfree (%)	15.7 / 17.7

The structure of Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Uranium atom in the Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium (pdb code 3s82). This binding sites where shown within 5.0 Angstroms radius around Uranium atom.
In total 2 binding sites of Uranium where determined in the Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium, PDB code: 3s82:
Jump to Uranium binding site number: 1; 2;

Uranium binding site 1 out of 2 in the Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium


Mono view


Stereo pair view

A full contact list of Uranium with other atoms in the U binding site number 1 of Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium within 5.0Å range: probe atom residue distance (Å) B Occ A:U406 b:82.8 occ:1.00 OE2 A:GLU45 2.5 22.8 1.0 O B:ALA260 2.9 13.0 1.0 CD A:GLU45 3.7 19.4 1.0 C B:ALA260 3.9 13.1 1.0 O B:HOH792 4.0 32.5 1.0 O A:HOH628 4.1 20.9 1.0 CG A:GLU45 4.2 12.7 1.0 OD2 B:ASP259 4.3 27.6 1.0 OD1 B:ASP19 4.3 10.0 1.0 NH2 B:ARG265 4.5 13.2 1.0 OD2 B:ASP19 4.6 12.7 1.0 OE1 A:GLU45 4.7 17.3 1.0 CA B:ALA260 4.7 14.0 1.0 CA B:GLY261 4.7 10.2 1.0 N B:GLY261 4.8 10.7 1.0 N B:ALA260 4.8 15.7 1.0 CB B:ALA260 4.8 13.7 1.0 O A:HOH707 4.9 24.4 1.0 CG B:ASP19 4.9 11.5 1.0

Uranium binding site 2 out of 2 in the Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium


Mono view


Stereo pair view

A full contact list of Uranium with other atoms in the U binding site number 2 of Structure of A S-Adenosylmethionine Synthetase From Mycobacterium Avium within 5.0Å range: probe atom residue distance (Å) B Occ A:U407 b:89.4 occ:1.00 O A:ALA260 2.6 14.0 1.0 OE2 B:GLU45 3.1 26.1 1.0 C A:ALA260 3.7 13.3 1.0 OD2 A:ASP259 3.7 28.8 1.0 O A:HOH501 4.0 40.7 1.0 CD B:GLU45 4.2 20.6 1.0 O B:HOH1777 4.3 26.9 1.0 OD1 A:ASP19 4.4 11.0 1.0 O B:HOH523 4.4 19.9 1.0 N A:ALA260 4.4 16.8 1.0 OD2 A:ASP19 4.5 11.8 1.0 CA A:ALA260 4.5 14.1 1.0 N A:GLY261 4.6 10.3 1.0 CG B:GLU45 4.6 14.8 1.0 CA A:GLY261 4.6 10.0 1.0 CB A:ALA260 4.8 13.2 1.0 CG A:ASP259 4.8 25.0 1.0 CG A:ASP19 4.8 11.2 1.0 NH2 A:ARG265 5.0 13.3 1.0

L.Baugh, I.Phan, D.W.Begley, M.C.Clifton, B.Armour, D.M.Dranow, B.M.Taylor, M.M.Muruthi, J.Abendroth, J.W.Fairman, D.Fox, S.H.Dieterich, B.L.Staker, A.S.Gardberg, R.Choi, S.N.Hewitt, A.J.Napuli, J.Myers, L.K.Barrett, Y.Zhang, M.Ferrell, E.Mundt, K.Thompkins, N.Tran, S.Lyons-Abbott, A.Abramov, A.Sekar, D.Serbzhinskiy, D.Lorimer, G.W.Buchko, R.Stacy, L.J.Stewart, T.E.Edwards, W.C.Van Voorhis, P.J.Myler. Increasing the Structural Coverage of Tuberculosis Drug Targets. Tuberculosis (Edinb) V. 95 142 2015.
ISSN: ISSN 1472-9792
PubMed: 25613812
DOI: 10.1016/J.TUBE.2014.12.003