Uranium in PDB 7b2w: Torpedo Californica Acetylcholinesterase Complexed with UO2

All present enzymatic activity of Torpedo Californica Acetylcholinesterase Complexed with UO2:
3.1.1.7;

The structure of Torpedo Californica Acetylcholinesterase Complexed with UO2, PDB code: 7b2w was solved by I.Silman, V.L.Shnyrov, Y.Ashani, E.Roth, A.Nicolas, J.L.Sussman, L.Weiner, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.09 / 2.65
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	110.88, 110.88, 134.67, 90, 90, 120
R / Rfree (%)	16.1 / 21.2

The binding sites of Uranium atom in the Torpedo Californica Acetylcholinesterase Complexed with UO2 (pdb code 7b2w). This binding sites where shown within 5.0 Angstroms radius around Uranium atom.
In total 2 binding sites of Uranium where determined in the Torpedo Californica Acetylcholinesterase Complexed with UO2, PDB code: 7b2w:
Jump to Uranium binding site number: 1; 2;

Uranium binding site 1 out of 2 in the Torpedo Californica Acetylcholinesterase Complexed with UO2


Mono view


Stereo pair view

A full contact list of Uranium with other atoms in the U binding site number 1 of Torpedo Californica Acetylcholinesterase Complexed with UO2 within 5.0Å range: probe atom residue distance (Å) B Occ A:U601 b:48.8 occ:1.00 U A:IUM601 0.0 48.8 1.0 O1 A:IUM601 2.2 53.3 1.0 OD1 A:ASP326 2.3 38.7 1.0 O2 A:IUM601 2.3 35.6 1.0 OD1 A:ASP393 3.0 37.9 1.0 CG A:ASP326 3.5 31.0 1.0 CG A:ASP393 3.6 25.6 1.0 OD2 A:ASP393 3.7 34.4 1.0 CG A:ASP392 3.8 36.2 1.0 OD1 A:ASP392 3.8 58.3 1.0 OD2 A:ASP392 4.0 44.1 1.0 CB A:ASP392 4.2 24.0 1.0 O A:ASP389 4.2 31.6 1.0 O A:LYS325 4.2 30.2 1.0 CB A:ASP326 4.3 22.9 1.0 O A:HOH719 4.3 22.3 1.0 CA A:ASP326 4.3 25.8 1.0 NZ A:LYS325 4.3 61.7 1.0 NH2 A:ARG517 4.3 25.2 0.6 N A:ASP393 4.4 32.6 1.0 OD2 A:ASP326 4.4 31.6 1.0 CA A:ASP393 4.7 26.3 1.0 CB A:ASP393 4.8 31.4 1.0 C A:ASP392 4.8 28.8 1.0 C A:LYS325 4.8 31.9 1.0 CB A:ASP389 4.9 24.4 1.0 CE A:LYS325 4.9 38.0 1.0 C A:ASP389 4.9 22.8 1.0 N A:ASP326 4.9 29.4 1.0 CA A:ASP389 5.0 23.0 1.0

Uranium binding site 2 out of 2 in the Torpedo Californica Acetylcholinesterase Complexed with UO2


Mono view


Stereo pair view

A full contact list of Uranium with other atoms in the U binding site number 2 of Torpedo Californica Acetylcholinesterase Complexed with UO2 within 5.0Å range: probe atom residue distance (Å) B Occ A:U602 b:108.1 occ:1.00 U A:IUM602 0.0 108.1 1.0 O2 A:IUM602 2.2 64.7 1.0 O1 A:IUM602 2.2 76.4 1.0 OE1 A:GLU163 2.3 96.3 1.0 CD A:GLU163 3.4 85.5 1.0 OE2 A:GLU163 3.9 98.2 1.0 CG A:GLU260 3.9 33.6 1.0 NH1 A:ARG267 4.3 55.2 1.0 O A:GLU260 4.3 48.3 1.0 CG2 A:ILE263 4.6 42.7 1.0 CG A:GLU163 4.7 65.6 1.0 CB A:GLU260 4.7 40.8 1.0 CA A:GLU260 4.7 40.5 1.0 CB A:HIS264 4.9 54.8 1.0 C A:GLU260 4.9 46.4 1.0 N A:HIS264 5.0 51.4 1.0

I.Silman, V.L.Shnyrov, Y.Ashani, E.Roth, A.Nicolas, J.L.Sussman, L.Weiner. Torpedo Californica Acetylcholinesterase Is Stabilized By Binding of A Divalent Metal Ion to A Novel and Versatile 4D Motif To Be Published.